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Found 325 results
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2018
A Willsey J
,
Morris MT
,
Wang S
,
Willsey HR
,
Sun N
,
Teerikorpi N
,
Baum TB
,
Cagney G
,
Bender KJ
,
Desai TA
et al.
. 2018.
The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.
.
Cell. 174(3):505-520.
Gupta I
,
Collier PG
,
Haase B
,
Mahfouz A
,
Joglekar A
,
Floyd T
,
Koopmans F
,
Barres B
,
Smit AB
,
Sloan SA
et al.
. 2018.
Single-cell isoform RNA sequencing characterizes isoforms in thousands of cerebellar cells.
.
Nat Biotechnol.
Min S-W
,
Sohn PDongmin
,
Li Y
,
Devidze N
,
Johnson JR
,
Krogan NJ
,
Masliah E
,
Mok S-A
,
Gestwicki JE
,
Gan L
. 2018.
SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy.
.
J Neurosci. 38(15):3680-3688.
Tracy TE
,
Gan L
. 2018.
Tau-mediated synaptic and neuronal dysfunction in neurodegenerative disease.
.
Curr Opin Neurobiol. 51:134-138.
Fernandopulle MS
,
Prestil R
,
Grunseich C
,
Wang C
,
Gan L
,
Ward ME
. 2018.
Transcription Factor-Mediated Differentiation of Human iPSCs into Neurons.
.
Curr Protoc Cell Biol. 79(1):e51.
Udeochu J
,
Sayed FA
,
Gan L
. 2018.
TREM2 and Amyloid Beta: A Love-Hate Relationship.
.
Neuron. 97(5):991-993.
2017
Sha SJ
,
Miller ZA
,
Min S-W
,
Zhou Y
,
Brown J
,
Mitic LL
,
Karydas A
,
Koestler M
,
Tsai R
,
Corbetta-Rastelli C
et al.
. 2017.
An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from gene mutations.
.
Alzheimers Dement (N Y). 3(4):507-512.
Tracy TE
,
Gan L
. 2017.
Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy.
.
Bioessays. 39(4)
Shi Y
,
Yamada K
,
Liddelow SAntony
,
Smith ST
,
Zhao L
,
Luo W
,
Tsai RM
,
Spina S
,
Grinberg LT
,
Rojas JC
et al.
. 2017.
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
.
Nature. 549(7673):523-527.
Cao J
,
Gaamouch FEl
,
Meabon JS
,
Meeker KD
,
Zhu L
,
Zhong MB
,
Bendik J
,
Elder G
,
Jing P
,
Xia J
et al.
. 2017.
ApoE4-associated phospholipid dysregulation contributes to development of Tau hyper-phosphorylation after traumatic brain injury.
.
Sci Rep. 7(1):11372.
Ward ME
,
Chen R
,
Huang H-Y
,
Ludwig C
,
Telpoukhovskaia M
,
Taubes A
,
Boudin H
,
Minami SS
,
Reichert M
,
Albrecht P
et al.
. 2017.
Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.
.
Sci Transl Med. 9(385)
Boselli M
,
Lee B-H
,
Robert J
,
Prado MA
,
Min S-W
,
Cheng C
,
M Silva C
,
Seong C
,
Elsasser S
,
Hatle KM
et al.
. 2017.
An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.
.
J Biol Chem. 292(47):19209-19225.
Orr AL
,
Rutaganira FU
,
de Roulet D
,
Huang EJ
,
Hertz NT
,
Shokat KM
,
Nakamura K
. 2017.
Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.
.
Neurochem Int. 109:106-116.
Pathak D
,
Berthet A
,
Bendor JT
,
Yu K
,
Sellnow RC
,
Orr AL
,
Nguyen MK
,
Edwards RH
,
Manfredsson FP
,
Nakamura K
. 2017.
Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons.
.
eNeuro. 4(2)
Krabbe G
,
S Minami S
,
Etchegaray JI
,
Taneja P
,
Djukic B
,
Davalos D
,
Le D
,
Lo I
,
Zhan L
,
Reichert MC
et al.
. 2017.
Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.
.
Proc Natl Acad Sci U S A. 114(19):5029-5034.
Pineda A
,
Burré J
. 2017.
Modulating membrane binding of α-synuclein as a therapeutic strategy.
.
Proc Natl Acad Sci U S A. 114(6):1223-1225.
Wang C
,
Ward ME
,
Chen R
,
Liu K
,
Tracy TE
,
Chen X
,
Xie M
,
Sohn PDongmin
,
Ludwig C
,
Meyer-Franke A
et al.
. 2017.
Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening.
.
Stem Cell Reports. 9(4):1221-1233.
Krencik R
,
Seo K
,
van Asperen JV
,
Basu N
,
Cvetkovic C
,
Barlas S
,
Chen R
,
Ludwig C
,
Wang C
,
Ward ME
et al.
. 2017.
Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes.
.
Stem Cell Reports. 9(6):1745-1753.
2016
Sohn PDongmin
,
Tracy TE
,
Son H-I
,
Zhou Y
,
Leite REP
,
Miller BL
,
Seeley WW
,
Grinberg LT
,
Gan L
. 2016.
Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.
.
Mol Neurodegener. 11(1):47.
Tracy TE
,
Sohn PDongmin
,
S Minami S
,
Wang C
,
Min S-W
,
Li Y
,
Zhou Y
,
Le D
,
Lo I
,
Ponnusamy R
et al.
. 2016.
Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss.
.
Neuron. 90(2):245-60.
Möller T
,
Bard F
,
Bhattacharya A
,
Biber K
,
Campbell B
,
Dale E
,
Eder C
,
Gan L
,
Garden GA
,
Hughes ZA
et al.
. 2016.
Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.
.
Glia. 64(10):1788-94.
Faraco G
,
Park L
,
Zhou P
,
Luo W
,
Paul SM
,
Anrather J
,
Iadecola C
. 2016.
Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP.
.
J Cereb Blood Flow Metab. 36(1):241-52.
Zhao L
,
Gottesdiener AJ
,
Parmar M
,
Li M
,
Kaminsky SM
,
Chiuchiolo MJ
,
Sondhi D
,
Sullivan PM
,
Holtzman DM
,
Crystal RG
et al.
. 2016.
Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.
.
Neurobiol Aging. 44:159-72.
Bose A
,
M Beal F
. 2016.
Mitochondrial dysfunction in Parkinson's disease.
.
J Neurochem.
Brand MD
,
Goncalves RLS
,
Orr AL
,
Vargas L
,
Gerencser AA
,
Jensen MBorch
,
Wang YT
,
Melov S
,
Turk CN
,
Matzen JT
et al.
. 2016.
Suppressors of Superoxide-HO Production at Site I of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury.
.
Cell Metab. 24(4):582-592.
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