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Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 325 results
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2016
Wes PD, Sayed FA, Bard F, Gan L.  2016.  Targeting microglia for the treatment of Alzheimer's Disease.. Glia. 64(10):1710-32.
Yuan P, Condello C, C Keene D, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J.  2016.  TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.. Neuron. 92(1):252-264.
Yuan P, Condello C, C Keene D, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J.  2016.  TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.. Neuron. 90(4):724-39.
Bettayeb K, Chang JC, Luo W, Aryal S, Varotsis D, Randolph L, Netzer WJ, Greengard P, Flajolet M.  2016.  δ-COP modulates Aβ peptide formation via retrograde trafficking of APP.. Proc Natl Acad Sci U S A. 113(19):5412-7.
2015
Orr AG, Hsiao EC, Wang MM, Ho K, Kim DH, Wang X, Guo W, Kang J, Yu G-Q, Adame A et al..  2015.  Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.. Nat Neurosci. 18(3):423-34.
Kember RL, Georgi B, Bailey-Wilson JE, Stambolian D, Paul SM, Bućan M.  2015.  Copy number variants encompassing Mendelian disease genes in a large multigenerational family segregating bipolar disorder.. BMC Genet. 16:27.
Min S-W, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, S Minami S, Defensor E, Mok SAnn et al..  2015.  Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.. Nat Med. 21(10):1154-62.
Burré J, Sharma M, Südhof TC.  2015.  Definition of a molecular pathway mediating α-synuclein neurotoxicity.. J Neurosci. 35(13):5221-32.
Luo W, Liu W, Hu X, Hanna M, Caravaca A, Paul SM.  2015.  Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody.. Sci Rep. 5:11161.
S Minami S, Shen V, Le D, Krabbe G, Asgarov R, Perez-Celajes L, Lee C-H, Li J, Donnelly-Roberts D, Gan L.  2015.  Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists.. Biochem Pharmacol. 97(4):454-462.
Cho S-H, Chen JA, Sayed F, Ward ME, Gao F, Nguyen TA, Krabbe G, Sohn PDongmin, Lo I, Minami S et al..  2015.  SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β.. J Neurosci. 35(2):807-18.
Orr AL, Vargas L, Turk CN, Baaten JE, Matzen JT, Dardov VJ, Attle SJ, Li J, Quackenbush DC, Goncalves RLS et al..  2015.  Suppressors of superoxide production from mitochondrial complex III.. Nat Chem Biol. 11(11):834-6.
Burré J.  2015.  The Synaptic Function of α-Synuclein.. J Parkinsons Dis. 5(4):699-713.
Bacaj T, Wu D, Burré J, Malenka RC, Liu X, Südhof TC.  2015.  Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles.. PLoS Biol. 13(10):e1002267.
Kim KHye, Liu J, Galvin RJSells, Dage JL, Egeland JA, Smith RC, Merchant KM, Paul SM.  2015.  Transcriptomic Analysis of Induced Pluripotent Stem Cells Derived from Patients with Bipolar Disorder from an Old Order Amish Pedigree.. PLoS One. 10(11):e0142693.
2014
Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, Haas M et al..  2014.  2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.. Alzheimers Dement. 10(5 Suppl):S430-52.
Auclair JR, Salisbury JP, Johnson JL, Petsko GA, Ringe D, Bosco DA, Agar NYR, Santagata S, Durham HD, Agar JN.  2014.  Artifacts to avoid while taking advantage of top-down mass spectrometry based detection of protein S-thiolation.. Proteomics. 14(10):1152-7.
McKnight NC, Zhong Y, Wold MS, Gong S, Phillips GR, Dou Z, Zhao Y, Heintz N, Zong W-X, Yue Z.  2014.  Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex.. PLoS Genet. 10(10):e1004626.
Linsenbardt AJ, Taylor A, Emnett CM, Doherty JJ, Krishnan K, Covey DF, Paul SM, Zorumski CF, Mennerick S.  2014.  Different oxysterols have opposing actions at N-methyl-D-aspartate receptors.. Neuropharmacology. 85:232-42.
Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LHerl, Seeley WW et al..  2014.  Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.. J Exp Med. 211(10):1937-45.
Georgi B, Craig D, Kember RL, Liu W, Lindquist I, Nasser S, Brown C, Egeland JA, Paul SM, Bućan M.  2014.  Genomic view of bipolar disorder revealed by whole genome sequencing in a genetic isolate.. PLoS Genet. 10(3):e1004229.
Choi DW, Armitage R, Brady LS, Coetzee T, Fisher W, Hyman S, Pande A, Paul S, Potter W, Roin B et al..  2014.  Medicines for the mind: policy-based "pull" incentives for creating breakthrough CNS drugs.. Neuron. 84(3):554-63.
Acuna C, Guo Q, Burré J, Sharma M, Sun J, Südhof TC.  2014.  Microsecond dissection of neurotransmitter release: SNARE-complex assembly dictates speed and Ca²⁺ sensitivity.. Neuron. 82(5):1088-100.
Orr AL, Ashok D, Sarantos MR, Ng R, Shi T, Gerencser AA, Hughes RE, Brand MD.  2014.  Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase.. PLoS One. 9(2):e89938.
Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, Schneider RT, Petsko GA, Ringe D, Small SA.  2014.  Pharmacological chaperones stabilize retromer to limit APP processing.. Nat Chem Biol. 10(6):443-9.