Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

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Heintz N, Gong S. 2020. One-Step Bacterial Artificial Chromosome (BAC) Modification: Cloning of the A Homology Arm into Reporter-Shuttle Vector.. Cold Spring Harb Protoc. 2020(7):098111.

Heintz N, Gong S. 2020. Two-Step Bacterial Artificial Chromosome (BAC) Engineering: Cloning of the A and B Homology Arms into the Shuttle Vector.. Cold Spring Harb Protoc. 2020(4):098053.

Hey-Mogensen M, Goncalves RLS, Orr AL, Brand MD. 2014. Production of superoxide/H2O2 by dihydroorotate dehydrogenase in rat skeletal muscle mitochondria.. Free Radic Biol Med. 72:149-55.

Heymont J, Berenfeld L, Collins J, Kaganovich A, Maynes B, Moulin A, Ratskovskaya I, Poon PP, Johnston GC, Kamenetsky M et al.. 2000. TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation.. Proc Natl Acad Sci U S A. 97(23):12672-7.

Holtzman DM, Bales KR, Tenkova T, Fagan AM, Parsadanian M, Sartorius LJ, Mackey B, Olney J, McKeel D, Wozniak D et al.. 2000. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease.. Proc Natl Acad Sci U S A. 97(6):2892-7.

Holtzman DM, Bales KR, Wu S, Bhat P, Parsadanian M, Fagan AM, Chang LK, Sun Y, Paul SM. 1999. Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease.. J Clin Invest. 103(6):R15-R21.

Hu X, Li X, Zhao M, Gottesdiener A, Luo W, Paul S. 2014. Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40.. Mol Neurodegener. 9:52.

Hu W, Foord C, Hsu J, Fan L, Corley MJ, Lanjewar SN, Xu S, Belchikov N, He Y, Pang APS et al.. 2025. Combined single-cell profiling of chromatin-transcriptome and splicing across brain cell types, regions and disease state.. Nat Biotechnol.

Huang Y, Shenoy S, Lu B, Liu W, Li C. 2012. Kinase signaling dysfunction in Parkinson's disease: a reverse genetic approach in Drosophila.. J Neurogenet. 26(2):158-67.

Huang Y, Liu B, Sinha SC, Amin S, Gan L. 2023. Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders.. Mol Neurodegener. 18(1):79.

Huang Y, Fan L, Wong MYing, Lei Z, Krishnamachary B, Zhu D, Cadiz M, Nagiri RKumar, Ye P, Norman K et al.. 2026. cGAS-mediated IFN-I signaling contributes to disease progression in drug-refractory epilepsy.. bioRxiv.

Huang Y, Fan L, Wong MYing, Lei Z, Krishnamachary B, Zhu D, Cadiz MP, Nagiri RKumar, Ye P, Norman K et al.. 2026. cGAS-mediated type I IFN signaling contributes to disease progression in drug-refractory epilepsy.. Nat Neurosci.

Hunter JM, Cirrito JR, Restivo JL, Kinley RD, Sullivan PM, Holtzman DM, Koger D, DeLong C, Lin S, Zhao L et al.. 2012. Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice.. Brain Res. 1467:120-32.

Hurtado DE, Molina-Porcel L, Iba M, Aboagye AK, Paul SM, Trojanowski JQ, Lee VM-Y. 2010. A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model.. Am J Pathol. 177(4):1977-88.

Iannone AF, Akgül G, Zhang R, Wacks S, Hussein N, Macias CGinelly, Donatelle A, Bauriedel JMJ, Wright C, Abramov D et al.. 2024. The chemokine Cxcl14 regulates interneuron differentiation in layer I of the somatosensory cortex.. Cell Rep. 43(8):114531.

Inda MCarmen, Joshi S, Wang T, Bolaender A, Gandu S, Iii JKoren, Che AYue, Taldone T, Yan P, Sun W et al.. 2020. The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.. Nat Commun. 11(1):319.

Inoue K, Deng Z, Chen Y, Giannopoulou E, Xu R, Gong S, Greenblatt MB, Mangala LS, Lopez-Berestein G, Kirsch DG et al.. 2018. Bone protection by inhibition of microRNA-182.. Nat Commun. 9(1):4108.

Jati S, Taheri S, Kal S, Sinha SC, Head BP, Mahata SK, Sahoo D. 2025. Boolean Network Modeling Identifies Cognitive Resilience in the First Murine Model of Asymptomatic Alzheimer's Disease.. bioRxiv.

Joiner WJ, Tang MD, Wang LY, Dworetzky SI, Boissard CG, Gan L, Gribkoff VK, Kaczmarek LK. 1998. Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits.. Nat Neurosci. 1(6):462-9.

Ju S, Tardiff DF, Han H, Divya K, Zhong Q, Maquat LE, Bosco DA, Hayward LJ, Brown RH, Lindquist S et al.. 2011. A yeast model of FUS/TLS-dependent cytotoxicity.. PLoS Biol. 9(4):e1001052.

Ju H, Kim I-D, Pavlova I, Mu S, Park KWoo, Minkler J, Madkoor A, Wang W, Wang X, Wu Z et al.. 2025. Ischemic Conditioning Promotes Transneuronal Survival and Stroke Recovery via CD36-Mediated Efferocytosis.. Circ Res. 136(5):e34-e51.

Kaczmarek LK, Bhattacharjee A, Desai R, Gan L, Song P, von Hehn CAA, Whim MD, Yang B. 2005. Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels.. Hear Res. 206(1-2):133-45.

Kanemasa T, Gan L, Perney TM, Wang LY, Kaczmarek LK. 1995. Electrophysiological and pharmacological characterization of a mammalian Shaw channel expressed in NIH 3T3 fibroblasts.. J Neurophysiol. 74(1):207-17.

Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PDongmin, Bowles KR et al.. 2019. A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies.. Stem Cell Reports.

Kauppinen TM, Suh SWon, Higashi Y, Berman AE, Escartin C, Won SJoon, Wang C, Cho S-H, Gan L, Swanson RA. 2011. Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β.. J Neuroinflammation. 8:152.