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L
Bhattacharjee A
,
Gan L
,
Kaczmarek LK
. 2002.
Localization of the Slack potassium channel in the rat central nervous system.
.
J Comp Neurol. 454(3):241-54.
K
Kauwe G
,
Pareja-Navarro KA
,
Yao L
,
Chen JH
,
Wong I
,
Saloner R
,
Cifuentes H
,
Nana AL
,
Shah S
,
Li Y
et al.
. 2024.
KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.
.
J Clin Invest. 134(3)
Kauwe G
,
Pareja-Navarro KA
,
Yao L
,
Chen JH
,
Wong I
,
Saloner R
,
Cifuentes H
,
Nana AL
,
Shah S
,
Li Y
et al.
. 2023.
KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.
.
bioRxiv.
I
Esposito L
,
Gan L
,
Yu G-Q
,
Essrich C
,
Mucke L
. 2004.
Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
.
J Neurochem. 91(6):1260-74.
Boselli M
,
Lee B-H
,
Robert J
,
Prado MA
,
Min S-W
,
Cheng C
,
M Silva C
,
Seong C
,
Elsasser S
,
Hatle KM
et al.
. 2017.
An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.
.
J Biol Chem. 292(47):19209-19225.
Ward ME
,
Chen R
,
Huang H-Y
,
Ludwig C
,
Telpoukhovskaia M
,
Taubes A
,
Boudin H
,
Minami SS
,
Reichert M
,
Albrecht P
et al.
. 2017.
Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.
.
Sci Transl Med. 9(385)
Sun B
,
Halabisky B
,
Zhou Y
,
Palop JJ
,
Yu G
,
Mucke L
,
Gan L
. 2009.
Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease.
.
Cell Stem Cell. 5(6):624-33.
Gan L
,
Ye S
,
Chu A
,
Anton K
,
Yi S
,
Vincent VA
,
von Schack D
,
Chin D
,
Murray J
,
Lohr S
et al.
. 2004.
Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach.
.
J Biol Chem. 279(7):5565-72.
H
Bravo CParra
,
Giani AMaria
,
Madero-Pérez J
,
Zhao Z
,
Wan Y
,
Samelson AJ
,
Wong MYing
,
Evangelisti A
,
Cordes E
,
Fan L
et al.
. 2024.
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.
.
Cell. 187(10):2446-2464.e22.
Bravo CParra
,
Giani AMaria
,
Perez JMadero
,
Zhao Z
,
Samelson A
,
Wong MYing
,
Evangelisti A
,
Fan L
,
Pozner T
,
Mercedes M
et al.
. 2023.
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.
.
bioRxiv.
F
Yang X
,
Wen J
,
Yang H
,
Jones IR
,
Zhu X
,
Liu W
,
Li B
,
Clelland CD
,
Luo W
,
Wong MYing
et al.
. 2023.
Functional characterization of Alzheimer's disease genetic variants in microglia.
.
Nat Genet. 55(10):1735-1744.
Carling G
,
Luo W
,
Gan L
. 2023.
Friend turned foe: TREM2 agonist in battles against tau.
.
J Exp Med. 220(1)
Dong Q
,
Gentry NW
,
McMahon T
,
Yamazaki M
,
Benitez-Rivera L
,
Wang T
,
Gan L
,
Ptáček L
,
Fu Y-H
. 2022.
Familial natural short sleep mutations reduce Alzheimer pathology in mice.
.
iScience. 25(4):103964.
E
Chen X
,
Gan L
. 2019.
An exercise-induced messenger boosts memory in Alzheimer's disease.
.
Nat Med. 25(1):20-21.
Wang C
,
Telpoukhovskaia MA
,
Bahr BA
,
Chen X
,
Gan L
. 2018.
Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases.
.
Curr Opin Neurobiol. 48:52-58.
Ward ME
,
Taubes A
,
Chen R
,
Miller BL
,
Sephton CF
,
Gelfand JM
,
Minami S
,
Boscardin J
,
Martens LHerl
,
Seeley WW
et al.
. 2014.
Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.
.
J Exp Med. 211(10):1937-45.
D
Kodama L
,
Gan L
. 2019.
Do Microglial Sex Differences Contribute to Sex Differences in Neurodegenerative Diseases?
Trends Mol Med.
Telpoukhovskaia MA
,
Liu K
,
Sayed FA
,
Etchegaray JIker
,
Xie M
,
Zhan L
,
Li Y
,
Zhou Y
,
Le D
,
Bahr BA
et al.
. 2020.
Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia.
.
Sci Rep. 10(1):13688.
Sayed FA
,
Telpoukhovskaia M
,
Kodama L
,
Li Y
,
Zhou Y
,
Le D
,
Hauduc A
,
Ludwig C
,
Gao F
,
Clelland C
et al.
. 2018.
Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.
.
Proc Natl Acad Sci U S A. 115(40):10172-10177.
Chen H
,
Fan L
,
Guo Q
,
Wong MYing
,
Yu F
,
Foxe N
,
Wang W
,
Nessim A
,
Carling G
,
Liu B
et al.
. 2023.
DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity.
.
Res Sq.
C
Sun B
,
Zhou Y
,
Halabisky B
,
Lo I
,
Cho S-H
,
Mueller-Steiner S
,
Devidze N
,
Wang X
,
Grubb A
,
Gan L
. 2008.
Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.
.
Neuron. 60(2):247-57.
Cho S-H
,
Sun B
,
Zhou Y
,
Kauppinen TM
,
Halabisky B
,
Wes P
,
Ransohoff RM
,
Gan L
. 2011.
CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.
.
J Biol Chem. 286(37):32713-22.
Min S-W
,
Chen X
,
Tracy TE
,
Li Y
,
Zhou Y
,
Wang C
,
Shirakawa K
,
S Minami S
,
Defensor E
,
Mok SAnn
et al.
. 2015.
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.
.
Nat Med. 21(10):1154-62.
Möller T
,
Bard F
,
Bhattacharya A
,
Biber K
,
Campbell B
,
Dale E
,
Eder C
,
Gan L
,
Garden GA
,
Hughes ZA
et al.
. 2016.
Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.
.
Glia. 64(10):1788-94.
Dräger NM
,
Sattler SM
,
Huang CTzu-Ling
,
Teter OM
,
Leng K
,
Hashemi SHadi
,
Hong J
,
Aviles G
,
Clelland CD
,
Zhan L
et al.
. 2022.
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.
.
Nat Neurosci.
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