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Found 92 results
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Gan, Li
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Journal Article
Yan Y
,
Wang X
,
Chaput D
,
Shin M-K
,
Koh Y
,
Gan L
,
Pieper AA
,
Woo J-AA
,
Kang DE
. 2022.
X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women.
.
Cell. 185(21):3913-3930.e19.
Udeochu J
,
Sayed FA
,
Gan L
. 2018.
TREM2 and Amyloid Beta: A Love-Hate Relationship.
.
Neuron. 97(5):991-993.
Evering TH
,
Marston JL
,
Gan L
,
Nixon DF
. 2023.
Transposable elements and Alzheimer's disease pathogenesis.
.
Trends Neurosci. 46(3):170-172.
Fernandopulle MS
,
Prestil R
,
Grunseich C
,
Wang C
,
Gan L
,
Ward ME
. 2018.
Transcription Factor-Mediated Differentiation of Human iPSCs into Neurons.
.
Curr Protoc Cell Biol. 79(1):e51.
Gan L
. 2007.
Therapeutic potential of sirtuin-activating compounds in Alzheimer's disease.
.
Drug News Perspect. 20(4):233-9.
Tracy TE
,
Gan L
. 2018.
Tau-mediated synaptic and neuronal dysfunction in neurodegenerative disease.
.
Curr Opin Neurobiol. 51:134-138.
Tracy TE
,
Madero-Pérez J
,
Swaney DL
,
Chang TS
,
Moritz M
,
Konrad C
,
Ward ME
,
Stevenson E
,
Huttenhain R
,
Kauwe G
et al.
. 2022.
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
.
Cell. 185(4):712-728.e14.
Udeochu JC
,
Amin S
,
Huang Y
,
Fan L
,
Torres ERuth S
,
Carling GK
,
Liu B
,
McGurran H
,
Coronas-Samano G
,
Kauwe G
et al.
. 2023.
Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.
.
Nat Neurosci. 26(5):737-750.
Wes PD
,
Sayed FA
,
Bard F
,
Gan L
. 2016.
Targeting microglia for the treatment of Alzheimer's Disease.
.
Glia. 64(10):1710-32.
Krencik R
,
Seo K
,
van Asperen JV
,
Basu N
,
Cvetkovic C
,
Barlas S
,
Chen R
,
Ludwig C
,
Wang C
,
Ward ME
et al.
. 2017.
Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes.
.
Stem Cell Reports. 9(6):1745-1753.
Min S-W
,
Sohn PD
,
Cho S-H
,
Swanson RA
,
Gan L
. 2013.
Sirtuins in neurodegenerative diseases: an update on potential mechanisms.
.
Front Aging Neurosci. 5:53.
Chen J
,
Zhou Y
,
Mueller-Steiner S
,
Chen L-F
,
Kwon H
,
Yi S
,
Mucke L
,
Gan L
. 2005.
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.
.
J Biol Chem. 280(48):40364-74.
Cho S-H
,
Chen JA
,
Sayed F
,
Ward ME
,
Gao F
,
Nguyen TA
,
Krabbe G
,
Sohn PDongmin
,
Lo I
,
Minami S
et al.
. 2015.
SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β.
.
J Neurosci. 35(2):807-18.
Min S-W
,
Sohn PDongmin
,
Li Y
,
Devidze N
,
Johnson JR
,
Krogan NJ
,
Masliah E
,
Mok S-A
,
Gestwicki JE
,
Gan L
. 2018.
SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy.
.
J Neurosci. 38(15):3680-3688.
Hardwick SA
,
Hu W
,
Joglekar A
,
Fan L
,
Collier PG
,
Foord C
,
Balacco J
,
Lanjewar S
,
Sampson MMcGuirk
,
Koopmans F
et al.
. 2022.
Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue.
.
Nat Biotechnol.
Lopez-Lee C
,
Kodama L
,
Gan L
. 2021.
Sex Differences in Neurodegeneration: The Role of the Immune System in Humans.
.
Biol Psychiatry.
Lopez-Lee C
,
Kodama L
,
Fan L
,
Wong MYing
,
Foxe NR
,
Jiaz L
,
Yu F
,
Ye P
,
Zhu J
,
Norman K
et al.
. 2023.
Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During Aging.
.
bioRxiv.
S Minami S
,
Sun B
,
Popat K
,
Kauppinen T
,
Pleiss M
,
Zhou Y
,
Ward ME
,
Floreancig P
,
Mucke L
,
Desai T
et al.
. 2012.
Selective targeting of microglia by quantum dots.
.
J Neuroinflammation. 9:22.
Wang C
,
Ward ME
,
Chen R
,
Liu K
,
Tracy TE
,
Chen X
,
Xie M
,
Sohn PDongmin
,
Ludwig C
,
Meyer-Franke A
et al.
. 2017.
Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening.
.
Stem Cell Reports. 9(4):1221-1233.
Kaczmarek LK
,
Bhattacharjee A
,
Desai R
,
Gan L
,
Song P
,
von Hehn CAA
,
Whim MD
,
Yang B
. 2005.
Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels.
.
Hear Res. 206(1-2):133-45.
S Minami S
,
Shen V
,
Le D
,
Krabbe G
,
Asgarov R
,
Perez-Celajes L
,
Lee C-H
,
Li J
,
Donnelly-Roberts D
,
Gan L
. 2015.
Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists.
.
Biochem Pharmacol. 97(4):454-462.
Shin M-K
,
Vázquez-Rosa E
,
Koh Y
,
Dhar M
,
Chaubey K
,
Cintrón-Pérez CJ
,
Barker S
,
Miller E
,
Franke K
,
Noterman MF
et al.
. 2021.
Reducing acetylated tau is neuroprotective in brain injury.
.
Cell.
A Willsey J
,
Morris MT
,
Wang S
,
Willsey HR
,
Sun N
,
Teerikorpi N
,
Baum TB
,
Cagney G
,
Bender KJ
,
Desai TA
et al.
. 2018.
The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.
.
Cell. 174(3):505-520.
Zhan L
,
Krabbe G
,
Du F
,
Jones I
,
Reichert MC
,
Telpoukhovskaia M
,
Kodama L
,
Wang C
,
Cho S-H
,
Sayed F
et al.
. 2019.
Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain.
.
PLoS Biol. 17(2):e3000134.
Zhang F
,
Wang S
,
Gan L
,
Vosler PS
,
Gao Y
,
Zigmond MJ
,
Chen J
. 2011.
Protective effects and mechanisms of sirtuins in the nervous system.
.
Prog Neurobiol. 95(3):373-95.
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