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Found 28 results
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Orr, Adam L
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Journal Article
Wang C-E
,
Tydlacka S
,
Orr AL
,
Yang S-H
,
Graham RK
,
Hayden MR
,
Li S
,
Chan AWS
,
Li X-J
. 2008.
Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.
.
Hum Mol Genet. 17(17):2738-51.
Orr AG
,
Orr AL
,
Li X-J
,
Gross RE
,
Traynelis SF
. 2009.
Adenosine A(2A) receptor mediates microglial process retraction.
.
Nat Neurosci. 12(7):872-8.
Zimmer TS
,
Orr AL
,
Orr AG
. 2024.
Astrocytes in selective vulnerability to neurodegenerative disease.
.
Trends Neurosci. 47(4):289-302.
Licht-Murava A
,
Meadows SM
,
Palaguachi F
,
Song SC
,
Jackvony S
,
Bram Y
,
Zhou C
,
Schwartz RE
,
Froemke RC
,
Orr AL
et al.
. 2023.
Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines.
.
Sci Adv. 9(16):eade1282.
Pranski EL
,
Van Sanford CD
,
Dalal NV
,
Orr AL
,
Karmali D
,
Cooper DS
,
Costa N
,
Heilman CJ
,
Gearing M
,
Lah JJ
et al.
. 2012.
Comparative distribution of protein components of the A20 ubiquitin-editing complex in normal human brain.
.
Neurosci Lett. 520(1):104-9.
Murava ALicht
,
Meadows S
,
Palaguachi F
,
Song SC
,
Bram Y
,
Zhou C
,
Schwartz RE
,
Froemke RC
,
Orr AL
,
Orr AG
. 2021.
Dementia-linked TDP-43 dysregulation in astrocytes impairs memory, antiviral signaling, and chemokine-mediated astrocytic-neuronal interactions.
.
Alzheimers Dement. 17 Suppl 2:e058562.
Mastroberardino PG
,
Orr AL
,
Hu X
,
Na HMee
,
J Greenamyre T
. 2008.
A FRET-based method to study protein thiol oxidation in histological preparations.
.
Free Radic Biol Med. 45(7):971-81.
Li X-J
,
Orr AL
,
Li S
. 2010.
Impaired mitochondrial trafficking in Huntington's disease.
.
Biochim Biophys Acta. 1802(1):62-5.
Orr AL
,
Ashok D
,
Sarantos MR
,
Shi T
,
Hughes RE
,
Brand MD
. 2013.
Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening.
.
Free Radic Biol Med. 65:1047-1059.
Orr AL
,
Rutaganira FU
,
de Roulet D
,
Huang EJ
,
Hertz NT
,
Shokat KM
,
Nakamura K
. 2017.
Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.
.
Neurochem Int. 109:106-116.
Pathak D
,
Berthet A
,
Bendor JT
,
Yu K
,
Sellnow RC
,
Orr AL
,
Nguyen MK
,
Edwards RH
,
Manfredsson FP
,
Nakamura K
. 2017.
Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons.
.
eNeuro. 4(2)
Quinlan CL
,
Orr AL
,
Perevoshchikova IV
,
Treberg JR
,
Ackrell BA
,
Brand MD
. 2012.
Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions.
.
J Biol Chem. 287(32):27255-64.
Quinlan CL
,
Treberg JR
,
Perevoshchikova IV
,
Orr AL
,
Brand MD
. 2012.
Native rates of superoxide production from multiple sites in isolated mitochondria measured using endogenous reporters.
.
Free Radic Biol Med. 53(9):1807-17.
Orr AL
,
Kim C
,
Jimenez-Morales D
,
Newton BW
,
Johnson JR
,
Krogan NJ
,
Swaney DL
,
Mahley RW
. 2019.
Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function.
.
J Alzheimers Dis. 68(3):991-1011.
Pranski EL
,
Dalal NV
,
Herskowitz JH
,
Orr AL
,
Roesch LA
,
Fritz JJ
,
Heilman C
,
Lah JJ
,
Levey AI
,
Betarbet RS
. 2012.
Neuronal RING finger protein 11 (RNF11) regulates canonical NF-κB signaling.
.
J Neuroinflammation. 9:67.
Pranski E
,
Van Sanford CD
,
Dalal N
,
Orr AL
,
Karmali D
,
Cooper DS
,
Gearing M
,
Lah JJ
,
Levey AI
,
Betarbet R
. 2013.
NF-κB activity is inversely correlated to RNF11 expression in Parkinson's disease.
.
Neurosci Lett. 547:16-20.
Orr AL
,
Ashok D
,
Sarantos MR
,
Ng R
,
Shi T
,
Gerencser AA
,
Hughes RE
,
Brand MD
. 2014.
Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase.
.
PLoS One. 9(2):e89938.
Orr AL
,
Li S
,
Wang C-E
,
Li H
,
Wang J
,
Rong J
,
Xu X
,
Mastroberardino PGiorgio
,
J Greenamyre T
,
Li X-J
. 2008.
N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.
.
J Neurosci. 28(11):2783-92.
Wong H-S
,
Monternier P-A
,
Orr AL
,
Brand MD
. 2018.
Plate-Based Measurement of Superoxide and Hydrogen Peroxide Production by Isolated Mitochondria.
.
Methods Mol Biol. 1782:287-299.
Hey-Mogensen M
,
Goncalves RLS
,
Orr AL
,
Brand MD
. 2014.
Production of superoxide/H2O2 by dihydroorotate dehydrogenase in rat skeletal muscle mitochondria.
.
Free Radic Biol Med. 72:149-55.
Birket MJ
,
Orr AL
,
Gerencser AA
,
Madden DT
,
Vitelli C
,
Swistowski A
,
Brand MD
,
Zeng X
. 2011.
A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells.
.
J Cell Sci. 124(Pt 3):348-58.
Orr AL
,
Quinlan CL
,
Perevoshchikova IV
,
Brand MD
. 2012.
A refined analysis of superoxide production by mitochondrial sn-glycerol 3-phosphate dehydrogenase.
.
J Biol Chem. 287(51):42921-35.
Orr AL
,
Huang S
,
Roberts MA
,
Reed JC
,
Li S
,
Li X-J
. 2008.
Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice.
.
J Biol Chem. 283(23):16027-36.
Quinlan CL
,
Perevoshchikova IV
,
Hey-Mogensen M
,
Orr AL
,
Brand MD
. 2013.
Sites of reactive oxygen species generation by mitochondria oxidizing different substrates.
.
Redox Biol. 1:304-12.
Perevoshchikova IV
,
Quinlan CL
,
Orr AL
,
Gerencser AA
,
Brand MD
. 2013.
Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria.
.
Free Radic Biol Med. 61:298-309.
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