Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 410 results
Author [ Title(Desc)] Type Year
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Xia D, Lianoglou S, Sandmann T, Calvert M, Suh JH, Thomsen E, Dugas J, Pizzo ME, DeVos SL, Earr TK et al..  2022.  Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.. Mol Neurodegener. 17(1):41.
Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MBukar, Clelland CD, Cohen AD, Crary JF, Dage JL et al..  2024.  Novel avenues of tau research.. Alzheimers Dement.
Orr AL, Ashok D, Sarantos MR, Ng R, Shi T, Gerencser AA, Hughes RE, Brand MD.  2014.  Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase.. PLoS One. 9(2):e89938.
Orr AL, Li S, Wang C-E, Li H, Wang J, Rong J, Xu X, Mastroberardino PGiorgio, J Greenamyre T, Li X-J.  2008.  N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.. J Neurosci. 28(11):2783-92.
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Heintz N, Gong S.  2020.  One-Step Bacterial Artificial Chromosome (BAC) Modification: Cloning of the A Homology Arm into Reporter-Shuttle Vector.. Cold Spring Harb Protoc. 2020(7):098111.
Heintz N, Gong S.  2020.  One-Step Bacterial Artificial Chromosome (BAC) Modification: Preparation of Plasmids.. Cold Spring Harb Protoc. 2020(7):098095.
Heintz N, Gong S.  2020.  One-Step Bacterial Artificial Chromosome (BAC) Modification: Preparation of the A Homology Arm (A-Box).. Cold Spring Harb Protoc. 2020(7):098103.
Heintz N, Gong S.  2020.  One-Step Bacterial Artificial Chromosome (BAC) Modification: Transfer of the Reporter Vector into BAC/RecA Cells and Selection of Co-Integrates.. Cold Spring Harb Protoc. 2020(7):098137.
Heintz N, Gong S.  2020.  One-Step Bacterial Artificial Chromosome (BAC) Modification: Transformation of the BAC Host with the RecA Vector.. Cold Spring Harb Protoc. 2020(7):098129.
Petsko GA.  2013.  Open questions: Zombie projects, translational research, and the real secret of the inside of the cell.. BMC Biol. 11:97.
Kim J, Castellano JM, Jiang H, Basak JM, Parsadanian M, Pham V, Mason SM, Paul SM, Holtzman DM.  2009.  Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.. Neuron. 64(5):632-44.
X Yang W, Gong S.  2005.  An overview on the generation of BAC transgenic mice for neuroscience research.. Curr Protoc Neurosci. Chapter 5:Unit5.20.
Zhou W, Zhu M, Wilson MA, Petsko GA, Fink AL.  2006.  The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein.. J Mol Biol. 356(4):1036-48.
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Canet-Avilés RM, Wilson MA, Miller DW, Ahmad R, McLendon C, Bandyopadhyay S, Baptista MJ, Ringe D, Petsko GA, Cookson MR.  2004.  The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization.. Proc Natl Acad Sci U S A. 101(24):9103-8.
Sohn PDongmin, Huang CTzu-Ling, Yan R, Fan L, Tracy TE, Camargo CM, Montgomery KM, Arhar T, Mok S-A, Freilich R et al..  2019.  Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.. Neuron.
Gu X, Li C, Wei W, Lo V, Gong S, Li S-H, Iwasato T, Itohara S, Li X-J, Mody I et al..  2005.  Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice.. Neuron. 46(3):433-44.
Gan L, Mucke L.  2008.  Paths of convergence: sirtuins in aging and neurodegeneration.. Neuron. 58(1):10-4.
Xie L, Xie L.  2019.  Pathway-Centric Structure-Based Multi-Target Compound Screening for Anti-Virulence Drug Repurposing.. Int J Mol Sci. 20(14)
Luo W-jie, Wang H, Li H, Kim BS, Shah S, Lee H-J, Thinakaran G, Kim T-W, Yu G, Xu H.  2003.  PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.. J Biol Chem. 278(10):7850-4.
Luo W, Ip FCF, Fu G, Cheung K, Tian Y, Hu Y, Sinha A, Cheng EYL, Wu X, Bustos V et al..  2020.  A Pentacyclic Triterpene from Targets γ-Secretase.. ACS Chem Neurosci. 11(18):2827-2835.
DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM.  2001.  Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease.. Proc Natl Acad Sci U S A. 98(15):8850-5.
Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, Schneider RT, Petsko GA, Ringe D, Small SA.  2014.  Pharmacological chaperones stabilize retromer to limit APP processing.. Nat Chem Biol. 10(6):443-9.
Liu CFeng, Liu D, Momb J, Thomas PW, Lajoie A, Petsko GA, Fast W, Ringe D.  2013.  A phenylalanine clamp controls substrate specificity in the quorum-quenching metallo-γ-lactonase from Bacillus thuringiensis.. Biochemistry. 52(9):1603-10.
Sanchez-Mejia RO, Newman JW, Toh S, Yu G-Q, Zhou Y, Halabisky B, Cissé M, Scearce-Levie K, Cheng IH, Gan L et al..  2008.  Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease.. Nat Neurosci. 11(11):1311-8.
Liu W, Acín-Peréz R, Geghman KD, Manfredi G, Lu B, Li C.  2011.  Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission.. Proc Natl Acad Sci U S A. 108(31):12920-4.