Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 398 results

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Liu Q, He D, Xie L. 2019. Prediction of off-target specificity and cell-specific fitness of CRISPR-Cas System using attention boosted deep learning and network-based gene feature.. PLoS Comput Biol. 15(10):e1007480.

Lin L-C, Nana AL, Hepker M, Hwang J-HLee, Gaus SE, Spina S, Cosme CG, Gan L, Grinberg LT, Geschwind DH et al.. 2019. Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants.. Acta Neuropathol Commun. 7(1):159.

Tomishima MJ, Hadjantonakis A-K, Gong S, Studer L. 2007. Production of green fluorescent protein transgenic embryonic stem cells using the GENSAT bacterial artificial chromosome library.. Stem Cells. 25(1):39-45.

Hey-Mogensen M, Goncalves RLS, Orr AL, Brand MD. 2014. Production of superoxide/H2O2 by dihydroorotate dehydrogenase in rat skeletal muscle mitochondria.. Free Radic Biol Med. 72:149-55.

Martens LHerl, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min S-W, Gan L, Finkbeiner S, Huang EJ et al.. 2012. Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.. J Clin Invest. 122(11):3955-9.

S Minami S, Min S-W, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME et al.. 2014. Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.. Nat Med. 20(10):1157-64.

Chen X, Li Y, Wang C, Tang Y, Mok S-A, Tsai RM, Rojas JC, Karydas A, Miller BL, Boxer AL et al.. 2020. Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy.. Mol Neurodegener. 15(1):2.

Burré J, Vivona S, Diao J, Sharma M, Brunger AT, Südhof TC. 2013. Properties of native brain α-synuclein.. Nature. 498(7453):E4-6;discussionE6-7.

Sharma M, Burré J, Südhof TC. 2012. Proteasome inhibition alleviates SNARE-dependent neurodegeneration.. Sci Transl Med. 4(147):147ra113.

Zhang F, Wang S, Gan L, Vosler PS, Gao Y, Zigmond MJ, Chen J. 2011. Protective effects and mechanisms of sirtuins in the nervous system.. Prog Neurobiol. 95(3):373-95.

Bosco DA, LaVoie MJ, Petsko GA, Ringe D. 2011. Proteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis.. Cold Spring Harb Perspect Biol. 3(10):a007500.

Zhan L, Krabbe G, Du F, Jones I, Reichert MC, Telpoukhovskaia M, Kodama L, Wang C, Cho S-H, Sayed F et al.. 2019. Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain.. PLoS Biol. 17(2):e3000134.

A Willsey J, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA et al.. 2018. The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.. Cell. 174(3):505-520.

Lai CF, Gong SC, Esteban M. 1991. The purified 14-kilodalton envelope protein of vaccinia virus produced in Escherichia coli induces virus immunity in animals.. J Virol. 65(10):5631-5.

Blackwell DJ, Faggioni M, Wleklinski MJ, Gomez-Hurtado N, Venkataraman R, Gibbs CE, Baudenbacher FJ, Gong S, Fishman GI, Boyle PM et al.. 2022. The Purkinje-myocardial junction is the anatomical origin of ventricular arrhythmia in CPVT.. JCI Insight.

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Sigala PA, Fafarman AT, Schwans JP, Fried SD, Fenn TD, Caaveiro JMM, Pybus B, Ringe D, Petsko GA, Boxer SG et al.. 2013. Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site.. Proc Natl Acad Sci U S A. 110(28):E2552-61.

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Gong S, Kus L, Heintz N. 2010. Rapid bacterial artificial chromosome modification for large-scale mouse transgenesis.. Nat Protoc. 5(10):1678-96.

Rohan ML, Yamamoto RT, Ravichandran CT, Cayetano KR, Morales OG, Olson DP, Vitaliano G, Paul SM, Cohen BM. 2014. Rapid mood-elevating effects of low field magnetic stimulation in depression.. Biol Psychiatry. 76(3):186-93.

Bustos VHugo, Sunkari YKrishna, Sinha A, Pulina M, Bispo A, Hopkins M, Lam A, Kriegsman SF, Mui E, Chang E et al.. 2024. Rational Development of a Small-Molecule Activator of CK1γ2 That Decreases C99 and Beta-Amyloid Levels.. ACS Chem Biol. 19(1):37-47.

Lim H, He D, Qiu Y, Krawczuk P, Sun X, Xie L. 2019. Rational discovery of dual-indication multi-target PDE/Kinase inhibitor for precision anti-cancer therapy using structural systems pharmacology.. PLoS Comput Biol. 15(6):e1006619.

Kumar S, Singh SKumar, Viswakarma N, Sondarva G, Nair RSathish, Sethupathi P, Dorman M, Sinha SC, Hoskins K, Thatcher G et al.. 2020. Rationalized inhibition of mixed lineage kinase 3 and CD70 enhances life span and antitumor efficacy of CD8 T cells.. J Immunother Cancer. 8(2)

Witten IB, Steinberg EE, Lee SYeun, Davidson TJ, Zalocusky KA, Brodsky M, Yizhar O, Cho SL, Gong S, Ramakrishnan C et al.. 2011. Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement.. Neuron. 72(5):721-33.

Medrihan L, Umschweif G, Sinha A, Reed S, Lee J, Gindinova K, Sinha SC, Greengard P, Sagi Y. 2020. Reduced Kv3.1 Activity in Dentate Gyrus Parvalbumin Cells Induces Vulnerability to Depression.. Biol Psychiatry. 88(5):405-414.

Shin M-K, Vázquez-Rosa E, Koh Y, Dhar M, Chaubey K, Cintrón-Pérez CJ, Barker S, Miller E, Franke K, Noterman MF et al.. 2021. Reducing acetylated tau is neuroprotective in brain injury.. Cell.

S Minami S, Shen V, Le D, Krabbe G, Asgarov R, Perez-Celajes L, Lee C-H, Li J, Donnelly-Roberts D, Gan L. 2015. Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists.. Biochem Pharmacol. 97(4):454-462.