Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 397 results

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Chen X, Gan L. 2019. An exercise-induced messenger boosts memory in Alzheimer's disease.. Nat Med. 25(1):20-21.

Luo P, Yang F, Li J, Niemeyer JE, Zhan F, Estin J, Zhao M, Li D, Lin W, Liou J-Y et al.. 2023. Excitatory-inhibitory mismatch shapes node recruitment in an epileptic network.. Epilepsia. 64(7):1939-1950.

Heintz N, Gong S. 2019. Examination of Bacterial Artificial Chromosome (BAC) DNA Quality and Quantity by Pulsed-Field Gel Electrophoresis.. Cold Spring Harb Protoc. 2019(11)

Mukherjee K, Sharma M, Jahn R, Wahl MC, Südhof TC. 2010. Evolution of CASK into a Mg2+-sensitive kinase.. Sci Signal. 3(119):ra33.

Inda MCarmen, Joshi S, Wang T, Bolaender A, Gandu S, Iii JKoren, Che AYue, Taldone T, Yan P, Sun W et al.. 2020. The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.. Nat Commun. 11(1):319.

Cai T, Xie L, Zhang S, Chen M, He D, Badkul A, Liu Y, Namballa HKrishna, Dorogan M, Harding WW et al.. 2023. End-to-end sequence-structure-function meta-learning predicts genome-wide chemical-protein interactions for dark proteins.. PLoS Comput Biol. 19(1):e1010851.

Wang C, Telpoukhovskaia MA, Bahr BA, Chen X, Gan L. 2018. Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases.. Curr Opin Neurobiol. 48:52-58.

Hunter JM, Cirrito JR, Restivo JL, Kinley RD, Sullivan PM, Holtzman DM, Koger D, DeLong C, Lin S, Zhao L et al.. 2012. Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice.. Brain Res. 1467:120-32.

Xie L, Xie L. 2023. Elucidation of genome-wide understudied proteins targeted by PROTAC-induced degradation using interpretable machine learning.. PLoS Comput Biol. 19(8):e1010974.

Kanemasa T, Gan L, Perney TM, Wang LY, Kaczmarek LK. 1995. Electrophysiological and pharmacological characterization of a mammalian Shaw channel expressed in NIH 3T3 fibroblasts.. J Neurophysiol. 74(1):207-17.

Bodick NC, Offen WW, Levey AI, Cutler NR, Gauthier SG, Satlin A, Shannon HE, Tollefson GD, Rasmussen K, Bymaster FP et al.. 1997. Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease.. Arch Neurol. 54(4):465-73.

Lieberman RL, J D'Aquino A, Ringe D, Petsko GA. 2009. Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability.. Biochemistry. 48(22):4816-27.

Garcia CP, Licht-Murava A, Orr AG. 2023. Effects of adenosine A2A receptors on cognitive function in health and disease.. Int Rev Neurobiol. 170:121-154.

Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LHerl, Seeley WW et al.. 2014. Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.. J Exp Med. 211(10):1937-45.

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Kodama L, Gan L. 2019. Do Microglial Sex Differences Contribute to Sex Differences in Neurodegenerative Diseases? Trends Mol Med.

Sokhi UK, Liber MP, Frye L, Park S, Kang K, Pannellini T, Zhao B, Norinsky R, Ivashkiv LB, Gong S. 2018. Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models.. Nat Commun. 9(1):658.

Guiberson NGuy Lewis, Black LS, Haller JE, Brukner A, Abramov D, Ahmad S, Xie YXin, Sharma M, Burré J. 2024. Disease-linked mutations in Munc18-1 deplete synaptic Doc2.. Brain.

Telpoukhovskaia MA, Liu K, Sayed FA, Etchegaray JIker, Xie M, Zhan L, Li Y, Zhou Y, Le D, Bahr BA et al.. 2020. Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia.. Sci Rep. 10(1):13688.

Gyoneva S, Orr AG, Traynelis SF. 2009. Differential regulation of microglial motility by ATP/ADP and adenosine.. Parkinsonism Relat Disord. 15 Suppl 3:S195-9.

Sayed FA, Telpoukhovskaia M, Kodama L, Li Y, Zhou Y, Le D, Hauduc A, Ludwig C, Gao F, Clelland C et al.. 2018. Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.. Proc Natl Acad Sci U S A. 115(40):10172-10177.

Linsenbardt AJ, Taylor A, Emnett CM, Doherty JJ, Krishnan K, Covey DF, Paul SM, Zorumski CF, Mennerick S. 2014. Different oxysterols have opposing actions at N-methyl-D-aspartate receptors.. Neuropharmacology. 85:232-42.

Lechardeur D, Drzymala L, Sharma M, Zylka D, Kinach R, Pacia J, Hicks C, Usmani N, Rommens JM, Lukacs GL. 2000. Determinants of the nuclear localization of the heterodimeric DNA fragmentation factor (ICAD/CAD).. J Cell Biol. 150(2):321-34.

Landon MR, Lieberman RL, Hoang QQ, Ju S, Caaveiro JMM, Orwig SD, Kozakov D, Brenke R, Chuang G-Y, Beglov D et al.. 2009. Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase.. J Comput Aided Mol Des. 23(8):491-500.

Murava ALicht, Meadows S, Palaguachi F, Song SC, Bram Y, Zhou C, Schwartz RE, Froemke RC, Orr AL, Orr AG. 2021. Dementia-linked TDP-43 dysregulation in astrocytes impairs memory, antiviral signaling, and chemokine-mediated astrocytic-neuronal interactions.. Alzheimers Dement. 17 Suppl 2:e058562.

Du K, Sharma M, Lukacs GL. 2005. The DeltaF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR.. Nat Struct Mol Biol. 12(1):17-25.