Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 424 results
Author Title [ Type(Asc)] Year
Journal Article
Georgi B, Craig D, Kember RL, Liu W, Lindquist I, Nasser S, Brown C, Egeland JA, Paul SM, Bućan M.  2014.  Genomic view of bipolar disorder revealed by whole genome sequencing in a genetic isolate.. PLoS Genet. 10(3):e1004229.
Ginns EI, St Jean P, Philibert RA, Galdzicka M, Damschroder-Williams P, Thiel B, Long RT, Ingraham LJ, Dalwaldi H, Murray MA et al..  1998.  A genome-wide search for chromosomal loci linked to mental health wellness in relatives at high risk for bipolar affective disorder among the Old Order Amish.. Proc Natl Acad Sci U S A. 95(26):15531-6.
Sparwasser T, Gong S, Li JYH, Eberl G.  2004.  General method for the modification of different BAC types and the rapid generation of BAC transgenic mice.. Genesis. 38(1):39-50.
Dodart J-C, Marr RA, Koistinaho M, Gregersen BM, Malkani S, Verma IM, Paul SM.  2005.  Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease.. Proc Natl Acad Sci U S A. 102(4):1211-6.
Bateman RJ, Siemers ER, Mawuenyega KG, Wen G, Browning KR, Sigurdson WC, Yarasheski KE, Friedrich SW, DeMattos RB, May PC et al..  2009.  A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system.. Ann Neurol. 66(1):48-54.
He G, Luo W, Li P, Remmers C, Netzer WJ, Hendrick J, Bettayeb K, Flajolet M, Gorelick F, Wennogle LP et al..  2010.  Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.. Nature. 467(7311):95-8.
Li L, Rutlin M, Abraira VE, Cassidy C, Kus L, Gong S, Jankowski MP, Luo W, Heintz N, H Koerber R et al..  2011.  The functional organization of cutaneous low-threshold mechanosensory neurons.. Cell. 147(7):1615-27.
Yang X, Wen J, Yang H, Jones IR, Zhu X, Liu W, Li B, Clelland CD, Luo W, Wong MYing et al..  2023.  Functional characterization of Alzheimer's disease genetic variants in microglia.. Nat Genet. 55(10):1735-1744.
Gao V, Briano JA, Komer LE, Burré J.  2023.  Functional and Pathological Effects of α-Synuclein on Synaptic SNARE Complexes.. J Mol Biol. 435(1):167714.
Liu Y, Jiang S, Li Y, Zhao S, Yun Z, Zhao Z-H, Zhang L, Wang G, Chen X, Manubens-Gil L et al..  2023.  Full-Spectrum Neuronal Diversity and Stereotypy through Whole Brain Morphometry.. Res Sq.
Carling G, Luo W, Gan L.  2023.  Friend turned foe: TREM2 agonist in battles against tau.. J Exp Med. 220(1)
Mastroberardino PG, Orr AL, Hu X, Na HMee, J Greenamyre T.  2008.  A FRET-based method to study protein thiol oxidation in histological preparations.. Free Radic Biol Med. 45(7):971-81.
Joiner WJ, Tang MD, Wang LY, Dworetzky SI, Boissard CG, Gan L, Gribkoff VK, Kaczmarek LK.  1998.  Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits.. Nat Neurosci. 1(6):462-9.
Oostrom M, Muniak MA, West RMEichler, Akers S, Pande P, Obiri M, Wang W, Bowyer K, Wu Z, Bramer LM et al..  2024.  Fine-tuning TrailMap: The utility of transfer learning to improve the performance of deep learning in axon segmentation of light-sheet microscopy images.. PLoS One. 19(3):e0293856.
Chaudry O, Ndukwe K, Xie L, Figueiredo-Pereira M, Serrano P, Rockwell P.  2022.  Females exhibit higher GluA2 levels and outperform males in active place avoidance despite increased amyloid plaques in TgF344-Alzheimer's rats.. Sci Rep. 12(1):19129.
Dong Q, Gentry NW, McMahon T, Yamazaki M, Benitez-Rivera L, Wang T, Gan L, Ptáček L, Fu Y-H.  2022.  Familial natural short sleep mutations reduce Alzheimer pathology in mice.. iScience. 25(4):103964.
Holtzman DM, Bales KR, Wu S, Bhat P, Parsadanian M, Fagan AM, Chang LK, Sun Y, Paul SM.  1999.  Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease.. J Clin Invest. 103(6):R15-R21.
Liu Y, Lim H, Xie L.  2022.  Exploration of chemical space with partial labeled noisy student self-training and self-supervised graph embedding.. BMC Bioinformatics. 23(Suppl 3):158.
Chen X, Gan L.  2019.  An exercise-induced messenger boosts memory in Alzheimer's disease.. Nat Med. 25(1):20-21.
Luo P, Yang F, Li J, Niemeyer JE, Zhan F, Estin J, Zhao M, Li D, Lin W, Liou J-Y et al..  2023.  Excitatory-inhibitory mismatch shapes node recruitment in an epileptic network.. Epilepsia. 64(7):1939-1950.
Heintz N, Gong S.  2019.  Examination of Bacterial Artificial Chromosome (BAC) DNA Quality and Quantity by Pulsed-Field Gel Electrophoresis.. Cold Spring Harb Protoc. 2019(11)
Mukherjee K, Sharma M, Jahn R, Wahl MC, Südhof TC.  2010.  Evolution of CASK into a Mg2+-sensitive kinase.. Sci Signal. 3(119):ra33.
Inda MCarmen, Joshi S, Wang T, Bolaender A, Gandu S, Iii JKoren, Che AYue, Taldone T, Yan P, Sun W et al..  2020.  The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.. Nat Commun. 11(1):319.
Cai T, Xie L, Zhang S, Chen M, He D, Badkul A, Liu Y, Namballa HKrishna, Dorogan M, Harding WW et al..  2023.  End-to-end sequence-structure-function meta-learning predicts genome-wide chemical-protein interactions for dark proteins.. PLoS Comput Biol. 19(1):e1010851.
Wang C, Telpoukhovskaia MA, Bahr BA, Chen X, Gan L.  2018.  Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases.. Curr Opin Neurobiol. 48:52-58.