Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 410 results

Author Title Type [ Year

]

2023

Garcia CP, Licht-Murava A, Orr AG. 2023. Effects of adenosine A2A receptors on cognitive function in health and disease.. Int Rev Neurobiol. 170:121-154.

Xie L, Xie L. 2023. Elucidation of genome-wide understudied proteins targeted by PROTAC-induced degradation using interpretable machine learning.. PLoS Comput Biol. 19(8):e1010974.

Cai T, Xie L, Zhang S, Chen M, He D, Badkul A, Liu Y, Namballa HKrishna, Dorogan M, Harding WW et al.. 2023. End-to-end sequence-structure-function meta-learning predicts genome-wide chemical-protein interactions for dark proteins.. PLoS Comput Biol. 19(1):e1010851.

Luo P, Yang F, Li J, Niemeyer JE, Zhan F, Estin J, Zhao M, Li D, Lin W, Liou J-Y et al.. 2023. Excitatory-inhibitory mismatch shapes node recruitment in an epileptic network.. Epilepsia. 64(7):1939-1950.

Carling G, Luo W, Gan L. 2023. Friend turned foe: TREM2 agonist in battles against tau.. J Exp Med. 220(1)

Liu Y, Jiang S, Li Y, Zhao S, Yun Z, Zhao Z-H, Zhang L, Wang G, Chen X, Manubens-Gil L et al.. 2023. Full-Spectrum Neuronal Diversity and Stereotypy through Whole Brain Morphometry.. Res Sq.

Gao V, Briano JA, Komer LE, Burré J. 2023. Functional and Pathological Effects of α-Synuclein on Synaptic SNARE Complexes.. J Mol Biol. 435(1):167714.

Yang X, Wen J, Yang H, Jones IR, Zhu X, Liu W, Li B, Clelland CD, Luo W, Wong MYing et al.. 2023. Functional characterization of Alzheimer's disease genetic variants in microglia.. Nat Genet. 55(10):1735-1744.

Wu Y, Liu Q, Xie L. 2023. Hierarchical multi-omics data integration and modeling predict cell-specific chemical proteomics and drug responses.. Cell Rep Methods. 3(4):100452.

Bravo CParra, Giani AMaria, Perez JMadero, Zhao Z, Samelson A, Wong MYing, Evangelisti A, Fan L, Pozner T, Mercedes M et al.. 2023. Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.. bioRxiv.

Kauwe G, Pareja-Navarro KA, Yao L, Chen JH, Wong I, Saloner R, Cifuentes H, Nana AL, Shah S, Li Y et al.. 2023. KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.. bioRxiv.

Huang Y, Liu B, Sinha SC, Amin S, Gan L. 2023. Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders.. Mol Neurodegener. 18(1):79.

Lai Y, Zhao C, Tian Z, Wang C, Fan J, Hu X, Tu J, Li T, Leitz J, Pfuetzner RA et al.. 2023. Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering.. Proc Natl Acad Sci U S A. 120(44):e2310174120.

Oliveros G, Wallace CH, Chaudry O, Liu Q, Qiu Y, Xie L, Rockwell P, Figueiredo-Pereira ME, Serrano PA. 2023. Repurposing ibudilast to mitigate Alzheimer's disease by targeting inflammation.. Brain. 146(3):898-911.

Liao Z, Xie L, Mamitsuka H, Zhu S. 2023. Sc2Mol: a scaffold-based two-step molecule generator with variational autoencoder and transformer.. Bioinformatics. 39(1)

Lopez-Lee C, Kodama L, Fan L, Wong MYing, Foxe NR, Jiaz L, Yu F, Ye P, Zhu J, Norman K et al.. 2023. Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During Aging.. bioRxiv.

Udeochu JC, Amin S, Huang Y, Fan L, Torres ERuth S, Carling GK, Liu B, McGurran H, Coronas-Samano G, Kauwe G et al.. 2023. Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.. Nat Neurosci. 26(5):737-750.

Evering TH, Marston JL, Gan L, Nixon DF. 2023. Transposable elements and Alzheimer's disease pathogenesis.. Trends Neurosci. 46(3):170-172.

Zhang S, Liu Y, Xie L. 2023. A universal framework for accurate and efficient geometric deep learning of molecular systems.. Sci Rep. 13(1):19171.

Sharma M, Burré J. 2023. α-Synuclein in synaptic function and dysfunction.. Trends Neurosci. 46(2):153-166.

2022

Burré J, Sharma M. 2022. Cellular And Small Animal Models Of Neurodegenerative Diseases.. J Vis Exp. (186)

Pham T-H, Qiu Y, Liu J, Zimmer S, O'Neill E, Xie L, Zhang P. 2022. Chemical-induced gene expression ranking and its application to pancreatic cancer drug repurposing.. Patterns (N Y). 3(4):100441.

Dräger NM, Sattler SM, Huang CTzu-Ling, Teter OM, Leng K, Hashemi SHadi, Hong J, Aviles G, Clelland CD, Zhan L et al.. 2022. A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.. Nat Neurosci.

Wu Y, Liu Q, Qiu Y, Xie L. 2022. Deep learning prediction of chemical-induced dose-dependent and context-specific multiplex phenotype responses and its application to personalized alzheimer's disease drug repurposing.. PLoS Comput Biol. 18(8):e1010367.

Cai T, Abbu KAlyssa, Liu Y, Xie L. 2022. DeepREAL: a deep learning powered multi-scale modeling framework for predicting out-of-distribution ligand-induced GPCR activity.. Bioinformatics. 38(9):2561-2570.