Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 398 results
Author [ Title(Asc)] Type Year
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Lee SHun, Sharma M, Südhof TC, Shen J.  2014.  Synaptic function of nicastrin in hippocampal neurons.. Proc Natl Acad Sci U S A. 111(24):8973-8.
Cirrito JR, Yamada KA, Finn MBeth, Sloviter RS, Bales KR, May PC, Schoepp DD, Paul SM, Mennerick S, Holtzman DM.  2005.  Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.. Neuron. 48(6):913-22.
Brand MD, Goncalves RLS, Orr AL, Vargas L, Gerencser AA, Jensen MBorch, Wang YT, Melov S, Turk CN, Matzen JT et al..  2016.  Suppressors of Superoxide-HO Production at Site I of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury.. Cell Metab. 24(4):582-592.
Orr AL, Vargas L, Turk CN, Baaten JE, Matzen JT, Dardov VJ, Attle SJ, Li J, Quackenbush DC, Goncalves RLS et al..  2015.  Suppressors of superoxide production from mitochondrial complex III.. Nat Chem Biol. 11(11):834-6.
Mullasseril P, Hansen KB, Vance KM, Ogden KK, Yuan H, Kurtkaya NL, Santangelo R, Orr AG, Le P, Vellano KM et al..  2010.  A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.. Nat Commun. 1:90.
Abramov D, Guiberson NGuy Lewis, Burré J.  2020.  STXBP1 encephalopathies: Clinical spectrum, disease mechanisms, and therapeutic strategies.. J Neurochem.
Lieberman RL, Wustman BA, Huertas P, Powe AC, Pine CW, Khanna R, Schlossmacher MG, Ringe D, Petsko GA.  2007.  Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.. Nat Chem Biol. 3(2):101-7.
Kreinbring CA, Remillard SP, Hubbard P, Brodkin HR, Leeper FJ, Hawksley D, Lai EY, Fulton C, Petsko GA, Ringe D.  2014.  Structure of a eukaryotic thiaminase I.. Proc Natl Acad Sci U S A. 111(1):137-42.
Auclair JR, Brodkin HR, J D'Aquino A, Petsko GA, Ringe D, Agar JN.  2013.  Structural consequences of cysteinylation of Cu/Zn-superoxide dismutase.. Biochemistry. 52(36):6145-50.
Das C, Hoang QQ, Kreinbring CA, Luchansky SJ, Meray RK, Ray SS, Lansbury PT, Ringe D, Petsko GA.  2006.  Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1.. Proc Natl Acad Sci U S A. 103(12):4675-80.
Lai CF, Gong SC, Esteban M.  1990.  Structural and functional properties of the 14-kDa envelope protein of vaccinia virus synthesized in Escherichia coli.. J Biol Chem. 265(36):22174-80.
Netzer WJ, Sinha A, Ghias M, Chang E, Gindinova K, Mui E, Seo J-S, Sinha SC.  2024.  Stretching the structural envelope of imatinib to reduce β-amyloid production by modulating both β- and γ-secretase cleavages of APP.. Front Chem. 12:1381205.
Auclair JR, Boggio KJ, Petsko GA, Ringe D, Agar JN.  2010.  Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis.. Proc Natl Acad Sci U S A. 107(50):21394-9.
Majewska MD, Harrison NL, Schwartz RD, Barker JL, Paul SM.  1986.  Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor.. Science. 232(4753):1004-7.
Gan L, Anton KE, Masterson BA, Vincent VAM, Ye S, Gonzalez-Zulueta M.  2002.  Specific interference with gene expression and gene function mediated by long dsRNA in neural cells.. J Neurosci Methods. 121(2):151-7.
Hamill CE, Goldshmidt A, Nicole O, McKeon RJ, Brat DJ, Traynelis SF.  2005.  Special lecture: glial reactivity after damage: implications for scar formation and neuronal recovery.. Clin Neurosurg. 52:29-44.
Heintz N, Gong S.  2020.  Small-Scale Preparations of Yeast DNA.. Cold Spring Harb Protoc. 2020(10)
Heintz N, Gong S.  2019.  Small-Scale Isolation of Bacterial Artificial Chromosome (BAC) DNA and Verification by Polymerase Chain Reaction (PCR).. Cold Spring Harb Protoc. 2019(11)
Liu Q, Lee B, Xie L.  2022.  Small molecule modulation of microbiota: a systems pharmacology perspective.. BMC Bioinformatics. 23(Suppl 3):403.
Perevoshchikova IV, Quinlan CL, Orr AL, Gerencser AA, Brand MD.  2013.  Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria.. Free Radic Biol Med. 61:298-309.
Quinlan CL, Perevoshchikova IV, Hey-Mogensen M, Orr AL, Brand MD.  2013.  Sites of reactive oxygen species generation by mitochondria oxidizing different substrates.. Redox Biol. 1:304-12.
Min S-W, Sohn PD, Cho S-H, Swanson RA, Gan L.  2013.  Sirtuins in neurodegenerative diseases: an update on potential mechanisms.. Front Aging Neurosci. 5:53.
Chen J, Zhou Y, Mueller-Steiner S, Chen L-F, Kwon H, Yi S, Mucke L, Gan L.  2005.  SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.. J Biol Chem. 280(48):40364-74.
Cho S-H, Chen JA, Sayed F, Ward ME, Gao F, Nguyen TA, Krabbe G, Sohn PDongmin, Lo I, Minami S et al..  2015.  SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β.. J Neurosci. 35(2):807-18.
Min S-W, Sohn PDongmin, Li Y, Devidze N, Johnson JR, Krogan NJ, Masliah E, Mok S-A, Gestwicki JE, Gan L.  2018.  SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy.. J Neurosci. 38(15):3680-3688.