Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 444 results

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Garcia CP, Licht-Murava A, Orr AG. 2023. Effects of adenosine A2A receptors on cognitive function in health and disease.. Int Rev Neurobiol. 170:121-154.

Lieberman RL, J D'Aquino A, Ringe D, Petsko GA. 2009. Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability.. Biochemistry. 48(22):4816-27.

Bodick NC, Offen WW, Levey AI, Cutler NR, Gauthier SG, Satlin A, Shannon HE, Tollefson GD, Rasmussen K, Bymaster FP et al.. 1997. Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease.. Arch Neurol. 54(4):465-73.

Kanemasa T, Gan L, Perney TM, Wang LY, Kaczmarek LK. 1995. Electrophysiological and pharmacological characterization of a mammalian Shaw channel expressed in NIH 3T3 fibroblasts.. J Neurophysiol. 74(1):207-17.

Xie L, Xie L. 2023. Elucidation of genome-wide understudied proteins targeted by PROTAC-induced degradation using interpretable machine learning.. PLoS Comput Biol. 19(8):e1010974.

Hunter JM, Cirrito JR, Restivo JL, Kinley RD, Sullivan PM, Holtzman DM, Koger D, DeLong C, Lin S, Zhao L et al.. 2012. Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice.. Brain Res. 1467:120-32.

Sinha S, Gan L, Pieper AA. 2025. Emerging approaches to bridging discovery science with clinical care in Alzheimer's disease.. Neurotherapeutics. 22(3):e00589.

Wang C, Telpoukhovskaia MA, Bahr BA, Chen X, Gan L. 2018. Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases.. Curr Opin Neurobiol. 48:52-58.

Cai T, Xie L, Zhang S, Chen M, He D, Badkul A, Liu Y, Namballa HKrishna, Dorogan M, Harding WW et al.. 2023. End-to-end sequence-structure-function meta-learning predicts genome-wide chemical-protein interactions for dark proteins.. PLoS Comput Biol. 19(1):e1010851.

Inda MCarmen, Joshi S, Wang T, Bolaender A, Gandu S, Iii JKoren, Che AYue, Taldone T, Yan P, Sun W et al.. 2020. The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.. Nat Commun. 11(1):319.

Mukherjee K, Sharma M, Jahn R, Wahl MC, Südhof TC. 2010. Evolution of CASK into a Mg2+-sensitive kinase.. Sci Signal. 3(119):ra33.

Heintz N, Gong S. 2019. Examination of Bacterial Artificial Chromosome (BAC) DNA Quality and Quantity by Pulsed-Field Gel Electrophoresis.. Cold Spring Harb Protoc. 2019(11)

Luo P, Yang F, Li J, Niemeyer JE, Zhan F, Estin J, Zhao M, Li D, Lin W, Liou J-Y et al.. 2023. Excitatory-inhibitory mismatch shapes node recruitment in an epileptic network.. Epilepsia. 64(7):1939-1950.

Chen X, Gan L. 2019. An exercise-induced messenger boosts memory in Alzheimer's disease.. Nat Med. 25(1):20-21.

Feng W, Aikedan A, Sinha SC, Gan L. 2026. Expanding roles of cGAS-STING signaling in neuroinflammation.. J Clin Invest. 136(11)

Liu Y, Lim H, Xie L. 2022. Exploration of chemical space with partial labeled noisy student self-training and self-supervised graph embedding.. BMC Bioinformatics. 23(Suppl 3):158.

Holtzman DM, Bales KR, Wu S, Bhat P, Parsadanian M, Fagan AM, Chang LK, Sun Y, Paul SM. 1999. Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease.. J Clin Invest. 103(6):R15-R21.

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Dong Q, Gentry NW, McMahon T, Yamazaki M, Benitez-Rivera L, Wang T, Gan L, Ptáček L, Fu Y-H. 2022. Familial natural short sleep mutations reduce Alzheimer pathology in mice.. iScience. 25(4):103964.

Chaudry O, Ndukwe K, Xie L, Figueiredo-Pereira M, Serrano P, Rockwell P. 2022. Females exhibit higher GluA2 levels and outperform males in active place avoidance despite increased amyloid plaques in TgF344-Alzheimer's rats.. Sci Rep. 12(1):19129.

Oostrom M, Muniak MA, West RMEichler, Akers S, Pande P, Obiri M, Wang W, Bowyer K, Wu Z, Bramer LM et al.. 2024. Fine-tuning TrailMap: The utility of transfer learning to improve the performance of deep learning in axon segmentation of light-sheet microscopy images.. PLoS One. 19(3):e0293856.

Joiner WJ, Tang MD, Wang LY, Dworetzky SI, Boissard CG, Gan L, Gribkoff VK, Kaczmarek LK. 1998. Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits.. Nat Neurosci. 1(6):462-9.

Mastroberardino PG, Orr AL, Hu X, Na HMee, J Greenamyre T. 2008. A FRET-based method to study protein thiol oxidation in histological preparations.. Free Radic Biol Med. 45(7):971-81.

Carling G, Luo W, Gan L. 2023. Friend turned foe: TREM2 agonist in battles against tau.. J Exp Med. 220(1)

Liu Y, Jiang S, Li Y, Zhao S, Yun Z, Zhao Z-H, Zhang L, Wang G, Chen X, Manubens-Gil L et al.. 2023. Full-Spectrum Neuronal Diversity and Stereotypy through Whole Brain Morphometry.. Res Sq.

Gao V, Briano JA, Komer LE, Burré J. 2023. Functional and Pathological Effects of α-Synuclein on Synaptic SNARE Complexes.. J Mol Biol. 435(1):167714.