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Found 42 results
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A
Sayed FA
,
Kodama L
,
Fan L
,
Carling GK
,
Udeochu JC
,
Le D
,
Li Q
,
Zhou L
,
Wong MYing
,
Horowitz R
et al.
. 2021.
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.
.
Sci Transl Med. 13(622):eabe3947.
Shi Y
,
Yamada K
,
Liddelow SAntony
,
Smith ST
,
Zhao L
,
Luo W
,
Tsai RM
,
Spina S
,
Grinberg LT
,
Rojas JC
et al.
. 2017.
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
.
Nature. 549(7673):523-527.
Cao J
,
Gaamouch FEl
,
Meabon JS
,
Meeker KD
,
Zhu L
,
Zhong MB
,
Bendik J
,
Elder G
,
Jing P
,
Xia J
et al.
. 2017.
ApoE4-associated phospholipid dysregulation contributes to development of Tau hyper-phosphorylation after traumatic brain injury.
.
Sci Rep. 7(1):11372.
B
Ayed M
,
Lim H
,
Xie L
. 2019.
Biological representation of chemicals using latent target interaction profile.
.
BMC Bioinformatics. 20(Suppl 24):674.
Inoue K
,
Deng Z
,
Chen Y
,
Giannopoulou E
,
Xu R
,
Gong S
,
Greenblatt MB
,
Mangala LS
,
Lopez-Berestein G
,
Kirsch DG
et al.
. 2018.
Bone protection by inhibition of microRNA-182.
.
Nat Commun. 9(1):4108.
C
Pham T-H
,
Qiu Y
,
Liu J
,
Zimmer S
,
O'Neill E
,
Xie L
,
Zhang P
. 2022.
Chemical-induced gene expression ranking and its application to pancreatic cancer drug repurposing.
.
Patterns (N Y). 3(4):100441.
Sharma M
,
Burré J
,
Bronk P
,
Zhang Y
,
Xu W
,
Südhof TC
. 2012.
CSPα knockout causes neurodegeneration by impairing SNAP-25 function.
.
EMBO J. 31(4):829-41.
D
Poleksic A
,
Xie L
. 2019.
Database of adverse events associated with drugs and drug combinations.
.
Sci Rep. 9(1):20025.
Wu Y
,
Liu Q
,
Qiu Y
,
Xie L
. 2022.
Deep learning prediction of chemical-induced dose-dependent and context-specific multiplex phenotype responses and its application to personalized alzheimer's disease drug repurposing.
.
PLoS Comput Biol. 18(8):e1010367.
Cai T
,
Abbu KAlyssa
,
Liu Y
,
Xie L
. 2022.
DeepREAL: a deep learning powered multi-scale modeling framework for predicting out-of-distribution ligand-induced GPCR activity.
.
Bioinformatics. 38(9):2561-2570.
Telpoukhovskaia MA
,
Liu K
,
Sayed FA
,
Etchegaray JIker
,
Xie M
,
Zhan L
,
Li Y
,
Zhou Y
,
Le D
,
Bahr BA
et al.
. 2020.
Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia.
.
Sci Rep. 10(1):13688.
Guiberson NGuy Lewis
,
Black LS
,
Haller JE
,
Brukner A
,
Abramov D
,
Ahmad S
,
Xie YXin
,
Sharma M
,
Burré J
. 2024.
Disease-linked mutations in Munc18-1 deplete synaptic Doc2.
.
Brain.
E
Xie L
,
Xie L
. 2023.
Elucidation of genome-wide understudied proteins targeted by PROTAC-induced degradation using interpretable machine learning.
.
PLoS Comput Biol. 19(8):e1010974.
Xie L
,
Xie L
. 2023.
Elucidation of genome-wide understudied proteins targeted by PROTAC-induced degradation using interpretable machine learning.
.
PLoS Comput Biol. 19(8):e1010974.
Cai T
,
Xie L
,
Zhang S
,
Chen M
,
He D
,
Badkul A
,
Liu Y
,
Namballa HKrishna
,
Dorogan M
,
Harding WW
et al.
. 2023.
End-to-end sequence-structure-function meta-learning predicts genome-wide chemical-protein interactions for dark proteins.
.
PLoS Comput Biol. 19(1):e1010851.
Cai T
,
Xie L
,
Zhang S
,
Chen M
,
He D
,
Badkul A
,
Liu Y
,
Namballa HKrishna
,
Dorogan M
,
Harding WW
et al.
. 2023.
End-to-end sequence-structure-function meta-learning predicts genome-wide chemical-protein interactions for dark proteins.
.
PLoS Comput Biol. 19(1):e1010851.
Inda MCarmen
,
Joshi S
,
Wang T
,
Bolaender A
,
Gandu S
,
Iii JKoren
,
Che AYue
,
Taldone T
,
Yan P
,
Sun W
et al.
. 2020.
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.
.
Nat Commun. 11(1):319.
Liu Y
,
Lim H
,
Xie L
. 2022.
Exploration of chemical space with partial labeled noisy student self-training and self-supervised graph embedding.
.
BMC Bioinformatics. 23(Suppl 3):158.
F
Chaudry O
,
Ndukwe K
,
Xie L
,
Figueiredo-Pereira M
,
Serrano P
,
Rockwell P
. 2022.
Females exhibit higher GluA2 levels and outperform males in active place avoidance despite increased amyloid plaques in TgF344-Alzheimer's rats.
.
Sci Rep. 12(1):19129.
G
Xu P
,
Chang JC
,
Zhou X
,
Wang W
,
Bamkole M
,
Wong E
,
Bettayeb K
,
Jiang L-L
,
Huang T
,
Luo W
et al.
. 2021.
GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease.
.
J Exp Med. 218(8)
Xu P
,
Chang JC
,
Zhou X
,
Wang W
,
Bamkole M
,
Wong E
,
Bettayeb K
,
Jiang L-L
,
Huang T
,
Luo W
et al.
. 2021.
GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease.
.
J Exp Med. 218(8)
H
Wu Y
,
Liu Q
,
Xie L
. 2023.
Hierarchical multi-omics data integration and modeling predict cell-specific chemical proteomics and drug responses.
.
Cell Rep Methods. 3(4):100452.
L
Xie YXue
,
Naseri NN
,
Fels J
,
Kharel P
,
Na Y
,
Lane D
,
Burré J
,
Sharma M
. 2022.
Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models.
.
Nat Commun. 13(1):4918.
M
Kuo S-H
,
Tasset I
,
Cheng MM
,
Diaz A
,
Pan M-K
,
Lieberman OJ
,
Hutten SJ
,
Alcalay RN
,
Kim S
,
Ximénez-Embún P
et al.
. 2022.
Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy.
.
Sci Adv. 8(6):eabm6393.
N
Xia D
,
Lianoglou S
,
Sandmann T
,
Calvert M
,
Suh JH
,
Thomsen E
,
Dugas J
,
Pizzo ME
,
DeVos SL
,
Earr TK
et al.
. 2022.
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.
.
Mol Neurodegener. 17(1):41.
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