Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 40 results
Author Title [ Type(Asc)] Year
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Journal Article
Yuan P, Condello C, C Keene D, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J.  2016.  TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.. Neuron. 90(4):724-39.
Yuan P, Condello C, C Keene D, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J.  2016.  TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.. Neuron. 92(1):252-264.
Kim KHye, Liu J, Galvin RJSells, Dage JL, Egeland JA, Smith RC, Merchant KM, Paul SM.  2015.  Transcriptomic Analysis of Induced Pluripotent Stem Cells Derived from Patients with Bipolar Disorder from an Old Order Amish Pedigree.. PLoS One. 10(11):e0142693.
Paul SM.  2011.  Therapeutic antibodies for brain disorders.. Sci Transl Med. 3(84):84ps20.
Cirrito JR, Yamada KA, Finn MBeth, Sloviter RS, Bales KR, May PC, Schoepp DD, Paul SM, Mennerick S, Holtzman DM.  2005.  Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.. Neuron. 48(6):913-22.
Siemers ER, Friedrich S, Dean RA, Gonzales CR, Farlow MR, Paul SM, DeMattos RB.  2010.  Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease.. Clin Neuropharmacol. 33(2):67-73.
Rohan ML, Yamamoto RT, Ravichandran CT, Cayetano KR, Morales OG, Olson DP, Vitaliano G, Paul SM, Cohen BM.  2014.  Rapid mood-elevating effects of low field magnetic stimulation in depression.. Biol Psychiatry. 76(3):186-93.
Strauss KA, Markx S, Georgi B, Paul SM, Jinks RN, Hoshi T, McDonald A, First MB, Liu W, Benkert AR et al..  2014.  A population-based study of KCNH7 p.Arg394His and bipolar spectrum disorder.. Hum Mol Genet. 23(23):6395-406.
Kim J, Castellano JM, Jiang H, Basak JM, Parsadanian M, Pham V, Mason SM, Paul SM, Holtzman DM.  2009.  Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.. Neuron. 64(5):632-44.
Zhou Y, Su Y, Li B, Liu F, Ryder JW, Wu X, Gonzalez-DeWhitt PA, Gelfanova V, Hale JE, May PC et al..  2003.  Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho.. Science. 302(5648):1215-7.
Zorumski CF, Paul SM, Izumi Y, Covey DF, Mennerick S.  2013.  Neurosteroids, stress and depression: potential therapeutic opportunities.. Neurosci Biobehav Rev. 37(1):109-22.
Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, von Arnim CAF, Breiderhoff T, Jansen P, Wu X et al..  2005.  Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.. Proc Natl Acad Sci U S A. 102(38):13461-6.
Luo W, Liu W, Hu X, Hanna M, Caravaca A, Paul SM.  2015.  Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody.. Sci Rep. 5:11161.
Saura J, Petegnief V, Wu X, Liang Y, Paul SM.  2003.  Microglial apolipoprotein E and astroglial apolipoprotein J expression in vitro: opposite effects of lipopolysaccharide.. J Neurochem. 85(6):1455-67.
Paul SM, Doherty JJ, Robichaud AJ, Belfort GM, Chow BY, Hammond RS, Crawford DC, Linsenbardt AJ, Shu H-J, Izumi Y et al..  2013.  The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors.. J Neurosci. 33(44):17290-300.
Zhao L, Lin S, Bales KR, Gelfanova V, Koger D, DeLong C, Hale J, Liu F, Hunter JM, Paul SM.  2009.  Macrophage-mediated degradation of beta-amyloid via an apolipoprotein E isoform-dependent mechanism.. J Neurosci. 29(11):3603-12.
Liang Y, Lin S, Beyer TP, Zhang Y, Wu X, Bales KR, DeMattos RB, May PC, Li SDan, Jiang X-C et al..  2004.  A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes.. J Neurochem. 88(3):623-34.
Zhao L, Gottesdiener AJ, Parmar M, Li M, Kaminsky SM, Chiuchiolo MJ, Sondhi D, Sullivan PM, Holtzman DM, Crystal RG et al..  2016.  Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.. Neurobiol Aging. 44:159-72.
Dodart J-C, Bales KR, Gannon KS, Greene SJ, DeMattos RB, Mathis C, DeLong CA, Wu S, Wu X, Holtzman DM et al..  2002.  Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.. Nat Neurosci. 5(5):452-7.
Faraco G, Park L, Zhou P, Luo W, Paul SM, Anrather J, Iadecola C.  2016.  Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP.. J Cereb Blood Flow Metab. 36(1):241-52.
Castellano JM, Kim J, Stewart FR, Jiang H, DeMattos RB, Patterson BW, Fagan AM, Morris JC, Mawuenyega KG, Cruchaga C et al..  2011.  Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.. Sci Transl Med. 3(89):89ra57.
Bales KR, Liu F, Wu S, Lin S, Koger D, DeLong C, Hansen JC, Sullivan PM, Paul SM.  2009.  Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.. J Neurosci. 29(21):6771-9.
Fagan AM, Watson M, Parsadanian M, Bales KR, Paul SM, Holtzman DM.  2002.  Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease.. Neurobiol Dis. 9(3):305-18.
Paul SM, Mytelka DS, Dunwiddie CT, Persinger CC, Munos BH, Lindborg SR, Schacht AL.  2010.  How to improve R&D productivity: the pharmaceutical industry's grand challenge.. Nat Rev Drug Discov. 9(3):203-14.
Georgi B, Craig D, Kember RL, Liu W, Lindquist I, Nasser S, Brown C, Egeland JA, Paul SM, Bućan M.  2014.  Genomic view of bipolar disorder revealed by whole genome sequencing in a genetic isolate.. PLoS Genet. 10(3):e1004229.