Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 444 results

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Kauwe G, Pareja-Navarro KA, Yao L, Chen JH, Wong I, Saloner R, Cifuentes H, Nana AL, Shah S, Li Y et al.. 2023. KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.. bioRxiv.

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Orr AG, Lo I, Schumacher H, Ho K, Gill M, Guo W, Kim DH, Knox A, Saito T, Saido TC et al.. 2018. Istradefylline reduces memory deficits in aging mice with amyloid pathology.. Neurobiol Dis. 110:29-36.

Ju H, Kim I-D, Pavlova I, Mu S, Park KWoo, Minkler J, Madkoor A, Wang W, Wang X, Wu Z et al.. 2025. Ischemic Conditioning Promotes Transneuronal Survival and Stroke Recovery via CD36-Mediated Efferocytosis.. Circ Res. 136(5):e34-e51.

Theofilas P, Wang C, Butler D, Morales DO, Petersen C, Ambrose A, Chin B, Yang T, Khan S, Ng R et al.. 2024. iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death.. Mol Cell Neurosci. 130:103954.

Zhao L, Gottesdiener AJ, Parmar M, Li M, Kaminsky SM, Chiuchiolo MJ, Sondhi D, Sullivan PM, Holtzman DM, Crystal RG et al.. 2016. Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.. Neurobiol Aging. 44:159-72.

Esposito L, Gan L, Yu G-Q, Essrich C, Mucke L. 2004. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.. J Neurochem. 91(6):1260-74.

Orr AG, Sharma A, Binder NB, Miller AH, Pearce BD. 2010. Interleukin-1 mediates long-term hippocampal dentate granule cell loss following postnatal viral infection.. J Mol Neurosci. 41(1):89-96.

Orr AL, Ashok D, Sarantos MR, Shi T, Hughes RE, Brand MD. 2013. Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening.. Free Radic Biol Med. 65:1047-1059.

Boselli M, Lee B-H, Robert J, Prado MA, Min S-W, Cheng C, M Silva C, Seong C, Elsasser S, Hatle KM et al.. 2017. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.. J Biol Chem. 292(47):19209-19225.

Wang S, Qi C, Rajpurohit C, Ghosh B, Xiong W, Wang B, Qi Y, Hwang SHee, Hammock BD, Li H et al.. 2025. Inhibition of soluble epoxide hydrolase confers neuroprotection and restores microglial homeostasis in a tauopathy mouse model.. Mol Neurodegener. 20(1):44.

Ward ME, Chen R, Huang H-Y, Ludwig C, Telpoukhovskaia M, Taubes A, Boudin H, Minami SS, Reichert M, Albrecht P et al.. 2017. Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.. Sci Transl Med. 9(385)

Sang T-K, Li C, Liu W, Rodriguez A, Abrams JM, S Zipursky L, Jackson GR. 2005. Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis.. Hum Mol Genet. 14(3):357-72.

Hansen KB, Mullasseril P, Dawit S, Kurtkaya NL, Yuan H, Vance KM, Orr AG, Kvist T, Ogden KK, Le P et al.. 2010. Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists.. J Pharmacol Exp Ther. 333(3):650-62.

Li X-J, Orr AL, Li S. 2010. Impaired mitochondrial trafficking in Huntington's disease.. Biochim Biophys Acta. 1802(1):62-5.

Morciano M, Burré J, Corvey C, Karas M, Zimmermann H, Volknandt W. 2005. Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis.. J Neurochem. 95(6):1732-45.

Burré J, Zimmermann H, Volknandt W. 2007. Immunoisolation and subfractionation of synaptic vesicle proteins.. Anal Biochem. 362(2):172-81.

Dodart J-C, Bales KR, Gannon KS, Greene SJ, DeMattos RB, Mathis C, DeLong CA, Wu S, Wu X, Holtzman DM et al.. 2002. Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.. Nat Neurosci. 5(5):452-7.

Sun B, Halabisky B, Zhou Y, Palop JJ, Yu G, Mucke L, Gan L. 2009. Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease.. Cell Stem Cell. 5(6):624-33.

Chen TN, Orr AL, Orr AG, Vacanti NM. 2025. Identifying Links between Alzheimer's Disease and Type 2 Diabetes through Proteomics.. J Proteome Res. 24(8):3733-3740.

Gan L, Ye S, Chu A, Anton K, Yi S, Vincent VA, von Schack D, Chin D, Murray J, Lohr S et al.. 2004. Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach.. J Biol Chem. 279(7):5565-72.

Alarcón-Espósito J, Nagiri RKumar, Gan L, Sinha SC. 2025. Identification and development of cGAS inhibitors and their uses to treat Alzheimer's disease.. Neurotherapeutics. 22(3):e00536.

Burré J, Zimmermann H, Volknandt W. 2007. Identification and characterization of SV31, a novel synaptic vesicle membrane protein and potential transporter.. J Neurochem. 103(1):276-87.

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Faraco G, Park L, Zhou P, Luo W, Paul SM, Anrather J, Iadecola C. 2016. Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP.. J Cereb Blood Flow Metab. 36(1):241-52.

Qu W, Fan L, Jang MWendy, Ye P, Cordes E, Aikedan A, Hu W, Nagiri RKumar, Wong MYing, Luo W et al.. 2026. Humanized tauopathy chimeras uncover microglial and lncRNA strategies for neuroprotection.. bioRxiv.

Bravo CParra, Giani AMaria, Perez JMadero, Zhao Z, Samelson A, Wong MYing, Evangelisti A, Fan L, Pozner T, Mercedes M et al.. 2023. Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.. bioRxiv.