Helen & Robert Appel Alzheimer’s Disease Research Institute

Publications

Found 397 results

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Kodama L, Guzman E, Etchegaray JI, Li Y, Sayed FA, Zhou L, Zhou Y, Zhan L, Le D, Udeochu JC et al.. 2019. Microglial microRNAs mediate sex-specific responses to tau pathology.. Nat Neurosci.

Wang C, Fan L, Khawaja RR, Liu B, Zhan L, Kodama L, Chin M, Li Y, Le D, Zhou Y et al.. 2022. Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.. Nat Commun. 13(1):1969.

Krabbe G, S Minami S, Etchegaray JI, Taneja P, Djukic B, Davalos D, Le D, Lo I, Zhan L, Reichert MC et al.. 2017. Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.. Proc Natl Acad Sci U S A. 114(19):5029-5034.

Acuna C, Guo Q, Burré J, Sharma M, Sun J, Südhof TC. 2014. Microsecond dissection of neurotransmitter release: SNARE-complex assembly dictates speed and Ca²⁺ sensitivity.. Neuron. 82(5):1088-100.

Snyder HM, Carare RO, DeKosky ST, de Leon MJ, Dykxhoorn D, Gan L, Gardner R, Hinds SR, Jaffee M, Lamb BT et al.. 2018. Military-related risk factors for dementia.. Alzheimers Dement. 14(12):1651-1662.

Chadman KK, Gong S, Scattoni ML, Boltuck SE, Gandhy SU, Heintz N, Crawley JN. 2008. Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice.. Autism Res. 1(3):147-58.

Sharma M, Pampinella F, Nemes C, Benharouga M, So J, Du K, Bache KG, Papsin B, Zerangue N, Stenmark H et al.. 2004. Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes.. J Cell Biol. 164(6):923-33.

Quinlan CL, Orr AL, Perevoshchikova IV, Treberg JR, Ackrell BA, Brand MD. 2012. Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions.. J Biol Chem. 287(32):27255-64.

Bose A, M Beal F. 2016. Mitochondrial dysfunction in Parkinson's disease.. J Neurochem.

Kumar S, Singh SKumar, Viswakarma N, Sondarva G, Nair RSathish, Sethupathi P, Sinha SC, Emmadi R, Hoskins K, Danciu O et al.. 2020. Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity.. Proc Natl Acad Sci U S A. 117(14):7961-7970.

Viswakarma N, Sondarva G, Principe DR, Nair RSathish, Kumar S, Singh SKumar, Das S, Sinha SC, Grippo PJ, Grimaldo S et al.. 2021. Mixed Lineage Kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development.. Cancer Lett. 515:1-13.

Gong S, X Yang W. 2005. Modification of bacterial artificial chromosomes (BACs) and preparation of intact BAC DNA for generation of transgenic mice.. Curr Protoc Neurosci. Chapter 5:Unit5.21.

Yang Z, Jiang H, Chaichanasakul T, Chachainasakul T, Gong S, Yang XWilliam, Heintz N, Lin S. 2006. Modified bacterial artificial chromosomes for zebrafish transgenesis.. Methods. 39(3):183-8.

Pineda A, Burré J. 2017. Modulating membrane binding of α-synuclein as a therapeutic strategy.. Proc Natl Acad Sci U S A. 114(6):1223-1225.

Guo M, Gong S, Maric S, Misulovin Z, Pack M, Mahnke K, Nussenzweig MC, Steinman RM. 2000. A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells.. Hum Immunol. 61(8):729-38.

Du H, Wong MYing, Zhang T, Santos MNunez, Hsu C, Zhang J, Yu H, Luo W, Hu F. 2021. A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses.. Life Sci Alliance. 4(7)

Mattos C, Bellamacina CR, Peisach E, Pereira A, Vitkup D, Petsko GA, Ringe D. 2006. Multiple solvent crystal structures: probing binding sites, plasticity and hydration.. J Mol Biol. 357(5):1471-82.

Kuo S-H, Tasset I, Cheng MM, Diaz A, Pan M-K, Lieberman OJ, Hutten SJ, Alcalay RN, Kim S, Ximénez-Embún P et al.. 2022. Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy.. Sci Adv. 8(6):eabm6393.

Li Y, Liu W, Oo TF, Wang L, Tang Y, Jackson-Lewis V, Zhou C, Geghman K, Bogdanov M, Przedborski S et al.. 2009. Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease.. Nat Neurosci. 12(7):826-8.

Beilina A, Van Der Brug M, Ahmad R, Kesavapany S, Miller DW, Petsko GA, Cookson MR. 2005. Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability.. Proc Natl Acad Sci U S A. 102(16):5703-8.

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Wang C, Zhao C, Hu X, Qiang J, Liu Z, Gu J, Zhang S, Li D, Zhang Y, Burré J et al.. 2024. N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine.. bioRxiv.

Zhu PK, W Zheng S, Zhang P, Jing M, Borden PM, Ali F, Guo K, Feng J, Marvin JS, Wang Y et al.. 2020. Nanoscopic Visualization of Restricted Nonvolume Cholinergic and Monoaminergic Transmission with Genetically Encoded Sensors.. Nano Lett. 20(6):4073-4083.

Quinlan CL, Treberg JR, Perevoshchikova IV, Orr AL, Brand MD. 2012. Native rates of superoxide production from multiple sites in isolated mitochondria measured using endogenous reporters.. Free Radic Biol Med. 53(9):1807-17.

Diao J, Burré J, Vivona S, Cipriano DJ, Sharma M, Kyoung M, Südhof TC, Brunger AT. 2013. Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2.. Elife. 2:e00592.

Martinez-Losa M, Tracy TE, Ma K, Verret L, Clemente-Perez A, Khan AS, Cobos I, Ho K, Gan L, Mucke L et al.. 2018. Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease.. Neuron. 98(1):75-89.e5.